CRHS is a four-letter acronym that may refer to a high school or health care system:

• Canyon Ridge High School in Twin Falls, Idaho, United States
• Centennial Regional High School in Greenfield Park, Quebec, Canada
• Central Regional High School in Berkeley Township, New Jersey, United States
• Charlottetown Rural High School in Charlottetown, Prince Edward Island, Canada
• Cinco Ranch High School in Katy, Texas, United States
• Cedar Ridge High school in Round Rock, Texas, United States
• Coginchaug Regional High School in Durham, Connecticut, United States
• Columbia River High School in Vancouver, Washington, United States
• Coon Rapids High School in Coon Rapids, Minnesota, United States
• Coral Reef High School in Richmond Heights, Florida, United States
• Cossatot River High School in Polk County, Arkansas
• Crystal River High School in Crystal River, Florida, United States
• Cumberland Regional High School in Cumberland County, New Jersey, United States
• Columbus Regional Healthcare System in Muscogee County, Georgia, United States